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Burnham Researchers Illuminate Complex Mechanisms that Regulate DNA Damage Control and Replication in the Cell Cycle
LA JOLLA, Calif., January 5, 2008Scientists at Burnham Institute for Medical Research have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Since Ddk is often deregulated in human cancers, this new understanding of its role in DNA damage control could help shape new cancer therapies.