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Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in …

December 5, 2009
biotech

[NEWS]

Leukemia and myeloproliferative disorders are serious and often deadly blood cancers. Research presented today at the 51st Annual Meeting of the American Society of Hematology introduces potential new treatment options and improved diagnostic methods for patients suffering from acute promyelocytic leukemia, chronic myeloid leukemia, infant acute lymphoblastic leukemia, and myelofibrosis that are based on a better understanding of the underlying genetic causes of these conditions. “Researcher…

Keeping the genie in the bottle: transgene biocontainment by excision in pollen

December 5, 2009
biotech

Hong S. Moon, Yi Li, C. Neal Stewart. Gene flow from transgenic plants is an environmental and regulatory concern. While biocontainment might be achieved using male sterility or transgenic mitigation tools, we believe that perhaps the….

Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production

December 5, 2009
biotech

Bo Mattiasson, Kosin Teeparuksapun, Martin Hedström. New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays use….

Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application

December 5, 2009
biotech

Doreen M. Floss, Kai Schallau, Stefan Rose-John, Udo Conrad, Jürgen Scheller. Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly useful property: that of a thermally responsive reversible phase transition. These characteristics make E….

Liposomal gene delivery mediated by tissue-engineered scaffolds

December 5, 2009
biotech

Mangesh Kulkarni, Udo Greiser, Timothy O’Brien, Abhay Pandit. In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of deli….

Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

December 5, 2009
biotech

Linda G. Otten, Frank Hollmann, Isabel W.C.E. Arends. The availability of tailored enzymes is crucial for the implementation of biocatalysis in organic chemistry. Enantioselectivity is one key parameter defining the usefulness of an enzyme and, there….

Single cells as experimentation units in lab-on-a-chip devices

December 5, 2009
biotech

Séverine Le Gac, Albert van den Berg. ‘Lab-on-a-chip’ technology (LOC) has now reached a mature state and is employed commonly in research in the life sciences. LOC devices make novel experimentation possible while providing a sophist….

De novo prediction of structured RNAs from genomic sequences

December 5, 2009
biotech

Jan Gorodkin, Ivo L. Hofacker, Elfar Torarinsson, Zizhen Yao, Jakob H. Havgaard, Walter L. Ruzzo. Growing recognition of the numerous, diverse and important roles played by non-coding RNA in all organisms motivates better elucidation of these cellular components. Comparative genomics is a powe….

Nanofiber micelles from the self-assembly of block copolymers

December 5, 2009
biotechnology

Jieshu Qian, Meng Zhang, Ian Manners, Mitchell A. Winnik. Micelles are formed when block copolymers are dissolved in solvents selective for one of the blocks. In contrast to micelles formed by surfactants, block copolymer micelles are generally more robu….

Monitoring protein interactions and dynamics with solvatochromic fluorophores

December 5, 2009
biotech

Galen S. Loving, Matthieu Sainlos, Barbara Imperiali. Solvatochromic fluorophores possess emission properties that are sensitive to the nature of the local microenvironment. These dyes have been exploited in applications ranging from the study of pro….