Scientists at The Scripps Research Institute and The Genome Institute of Singapore (GIS) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development. This detailed mapping is a significant move towards the success of targeted differentiation of stem cells into specific organs, which is a crucial consideration for stem cell therapy.
The study was published in the genomics journal Genome Research on February 4, 2010.
“The cells in our bodies have the same DNA sequence,” said Scripps Research Professor Jeanne Loring, who is a senior author of the paper with Chia-Lin Wei of the Genome Institute of Singapore and the National University of Singapore and Isidore Rigoutsos of IBM Thomas J. Watson Research Center. “Epigenetics is the process that determines what parts of the genome are active in different cell types, making a nerve cell, for example, different from a muscle cell.”