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For two decades, scientists have been pursuing a potential new way to treat bacterial infections, using naturally occurring proteins known as antimicrobial peptides (AMPs). Now, MIT scientists have recorded the first microscopic images showing the deadly effects of AMPs, most of which kill by poking holes in bacterial cell membranes.

Researchers in the laboratory of MIT Professor Angela Belcher modified an existing, extremely sensitive technique known as high-speed atomic force microscopy (AFM) to allow them to image the bacteria in real time. Their method, described in this Sunday’s online edition of Nature Nanotechnology, represents the first way to study living cells using high-resolution images recorded in rapid succession.

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