- De novo mutations revealed by whole-exome sequencing are strongly associated with autism
- Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
- Patterns and rates of exonic de novo mutations in autism spectrum disorders
When two unrelated children with autism diagnosis, in two different studies, have de novo mutations on the same gene, you’ve got to begin to believe there is something genetic going on… We are delaying marriage and having children later in life. Chance of de novo mutations increases with parental age. The pieces are coming together in autism research.